IgG4 subclass antibodies impair antitumor immunity in melanoma
نویسندگان
چکیده
منابع مشابه
IgG4 subclass antibodies impair antitumor immunity in melanoma.
Host-induced antibodies and their contributions to cancer inflammation are largely unexplored. IgG4 subclass antibodies are present in IL-10-driven Th2 immune responses in some inflammatory conditions. Since Th2-biased inflammation is a hallmark of tumor microenvironments, we investigated the presence and functional implications of IgG4 in malignant melanoma. Consistent with Th2 inflammation, C...
متن کاملAntibodies testing, Immunity and immunity passport in Covid-19
The global outbreak of coronavirus disease-2019 (COVID-19) has affected most countries in the world. Our knowledge of diagnostic tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is evolving, and it is important to have a clear understanding of the nature of the tests and the interpretation of their findings. In this paper, the purpose is to interpret the results of two typ...
متن کاملChemotherapy enhances vaccine-induced antitumor immunity in melanoma patients.
Combination of chemotherapy with cancer vaccines is currently regarded as a potentially valuable therapeutic approach for the treatment of some metastatic tumors, but optimal modalities remain unknown. We designed a phase I/II pilot study for evaluating the effects of dacarbazine (DTIC) on the immune response in HLA-A2(+) disease-free melanoma patients who received anticancer vaccination 1 day ...
متن کاملUncarboxylated Osteocalcin Induces Antitumor Immunity against Mouse Melanoma Cell Growth
Because of the poor response to chemotherapy and radiation therapy, new treatment approaches by immune-based therapy involving activated T cells are required for melanoma. We previously reported that the uncarboxylated form of osteocalcin (GluOC), derived from osteoblasts, potentially suppresses human prostate cancer cell proliferation by direct suppression of cell growth. However, the mechanis...
متن کاملDivergent Effects of 4-1BB Antibodies on Antitumor Immunity
4-1BB is an inducible receptor-like protein expressed rapidly by both CD4 and CD8 T-cells after activation. 4-1BB cross-linking, either by binding to 4-1BBL or by antibody ligation, delivers a costimulatory signal to enhance T-cell activation and proliferation. Previous studies have demonstrated that the administration of 4-1BB monoclonal antibodies (mAbs) induces antitumor immune responses. In...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2013
ISSN: 0021-9738
DOI: 10.1172/jci65579